Intestinal microbial structure can reveal your true physiological age


There are billions of bacteria in the digestive tract of the human body, even exceeding the number of cells in the human body.

 These bacteria can regulate your diet, immune function, nervous system, mood, health status and more. Of course, gut microbes are far more than these functions.

Recently, the world’s top scientific research journal Science published a study: Intestinal microbes are a precise biological clock that can truly reflect the age of human beings.

 According to the study, scientists can even use microbial agents to slow down aging and change age.

InSilico Medicine, an artificial intelligence startup based in Maryland, USA, recently studied 1,165 healthy people from around the world and collected a total of more than 3,600 intestinal samples. About one-third of them are from young people, one-third are from middle-aged people, and the remaining one-third are from the elderly.

Next, scientists use “machine learning” to analyze huge amounts of data. First, they trained their computer program, a deep learning algorithm, that loosely simulated how neurons work in the brain. This program analyzes 90% of the gut samples containing 95 different types of bacteria while reading the age of the body.

Then, this algorithm program predicts the age of the remaining 10% of the population. The results show that the predicted age value is very accurate and the error is no more than 4 years. At the same time, of the 95 bacteria, 39 are the most important bacteria for predicting age.

As people age, some microorganisms become more abundant, such as Eubacterium hallii, a bacteria that promotes intestinal metabolism. There are also some bacterial species, such as Bacteroides vulgatus, which is associated with ulcerative colitis.

 Vadim Gladyshev, a Harvard biologist who studies aging, says that changes in diet, sleep habits, and physical activity can cause these changes in bacterial species.

Insiico researcher Zhavoronkov believes that this “microbial aging clock” can be used to detect the rate of intestinal aging and the effects of changes in alcohol, antibiotics, probiotics or diet on life. It can also be used to compare healthy people and people with certain diseases, such as Alzheimer’s disease (Alzheimer’s disease), to observe changes in their intestinal microflora.

If this idea is validated, other age-predicted markers will also be included in the model, including the length of the telomere—a substance that decreases with age at the end of the chromosome.

These “biological aging clocks” combine to more accurately depict a person’s true physical age and health.

 It can also help researchers better test external factors such as drugs and foods, and whether they can affect the aging process—in other words, the “aging” disease may be treated.

Of course, one of the challenges in developing such a clock is that there is a huge difference in the microbial structure in the gut of people around the world.

 It is important to compare such studies between different populations to determine if there are similar signs of aging in different populations.

Finally, we have no way to clarify the changes in the structure of the gut micro–and the aging of humans, who is the cause of fruit. But no matter what, human aging is an important indicator of the physiological state of the human body, and everyone changes every second.


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